Manipulations supported are read/write of image files and operations on separate pixels, image regions, entire images, and volumes (stacks in ImageJ). ImageJ can read most of the widely used and significant formats used in biomedical images. NIH reports tens of thousands of downloads at a rate of about 24,000 per month currently. Topics covered are imaging abilities cross platform image formats support as of June 2004 extensions, including macros and plug-ins and imaging library. A very large and knowledgeable group makes up the user community for ImageJ. read more ImageJ is easy to use and can do many imaging manipulations. ImageJ is in the public domain and runs on any operating system (OS). Wayne Rasband of NIH has created ImageJ, an open source Java-written program that is now at version 1.31 and is used for many imaging applications, including those that that span the gamut from skin analysis to neuroscience.